Aeroporto Internazionale dell'Umbria – Perugia San Francesco d'Assisi is Umbria's principal airport, serving flights from London, Brussels and Bucharest, among others (Florence’s Amerigo Vespucci airport is also convenient for northern Umbria). Along the rails, the Rome–Florence line and Rome–Ancona line hit various destinations in Umbria. The E35/45 connects Umbria's capital, Perugia, with Rome from the south; and the E35 connects to Florence in the north.
While having your own wheels certainly makes it easier to reach those off-the-radar hill towns and rural corners of Umbria, it is possible to get to many places by public transport with a little pre-planning.
Buses head from Perugia to most towns in the area; check at the tourist office or the bus station for exact details. Trenitalia (www.trenitalia.com) sparsely criss-crosses Umbria, but Busitalia (www.fsbusitalia.it) fills in the blanks with bus and ferry services.
Your first port of call for mountain biking and road-cycling itineraries should be Bike in Umbria (http://bikeinumbria.it).