Named after the founders of Esquire magazine, who contributed the start-up money, this is the official fine-arts museum of the University of Chicago. The collection holds 5000 years' worth of works. Twentieth-century paintings and sculptures, Central European expressionism and East Asian art are the strong suits. De Goya, Warhol and Kandinsky are just a few of the big-name artists on offer. Frank Lloyd Wright's table and chairs mix in for good measure.
It only takes a half-hour or so to see the galleries. After that, grab a drink or bite at the front cafe. From September through mid-June, the museum stays open until 8pm on Thursdays.