A 2000-acre slough (pronounced 'slew'), this park is a great place to experience southwest Florida's flora and fauna. A 1.2-mile boardwalk trail is staffed by volunteers who help explain the epiphytes, cypress knees, migrating birds and nesting alligators you'll find. Wildlife-watchers should target the winter dry season. The wet summer season is also dramatic of course: at its peak, the entire slough becomes a forested stream up to 3ft deep. The nature center (open from 10am to 4pm Tuesday to Sunday) has excellent displays and offers free guided walks.
From Fort Myers, go south on Cleveland Ave/US 41, east on Colonial Blvd/Hwy 884, then south for 3 miles on Ortiz Ave (which becomes Six Mile Cypress Pkwy).