Plzeň train station has regular trains to Prague as well as to Mariánské Lázně, with onward connections to Karlovy Vary. The station is in an industrial area about 1km (15 minutes on foot) from the historic centre.
The Central Bus Station, often abbreviated locally as CAN, is 1km west of the centre, a straight shot down Husova street. Buses depart here for around the country, including RegioJet, Flixbus and other coaches.
Buy bus tickets here for journeys to Prague, as well as for RegioJet's train service to select cities in Moravia.