Route 66 Sign

Historic Site in The Loop
Image by Bruce Leighty / Getty Images

Attention Route 66 buffs: the Mother Road begins in downtown Chicago. Look for the 'Historic 66 Begin' sign at the northwestern corner of Adams St and Michigan Ave, across from the Art Institute. (There's another sign at the end of the block, but this one is a replica of the original.) From Chicago the route traverses 2400 miles to Los Angeles, past neon signs, mom-and-pop motels and pie-and-coffee diners…but it all starts here.