This 13th-century church was built as part of a Benedictine monastery. Its highlight is Domenico Ghirlandaio's fresco of the Madonna della Misericordia protecting members of the Vespucci family, the church's main patrons. Amerigo Vespucci, the Florentine navigator who gave his name to the American continent, is supposed to be the young boy whose head peeks between the Madonna and the old man. Also here are a Crucifixion by Taddeo Gaddi in the sacristy, and between the third and fourth altars a pensive St Augustine (1480) by Botticelli.
Botticelli's simple tombstone is also here. He had requested to be buried at the feet of Simonetta Vespucci, the married woman whom he was said to be in love with and who served as a model for one of his greatest masterpieces, Primavera (Spring). The round tombstone is in the south transept marked "Sandro Filipepi."