A stiff but scenic climb up from the old town, Ancona's perkily domed cathedral commands sweeping views of the city and port from its hilltop perch. Guarded by two marble lions, the cathedral sits grandly atop the site of an ancient pagan temple and is an architectural potpourri of Byzantine, Romanesque and Gothic features.

Wandering downhill from here along Piazza Anfiteatro, you will glimpse the remains of the city's Roman amphitheatre, believed to have been built during the reign of Emperor Augustus.