If ever there was a forgotten corner of the Netherlands, this is it. With no sea access or major city to call its own (postwar project Emmen is the largest), Drenthe is as Vincent van Gogh described in 1883: "Here is peace." His paintings of the peat collectors in the province's southeast bear him out.
Peace is exactly why this mostly rural region deserves some of your time. There's a growing collection of national parks, plus you get to explore the mysterious hunebedden (dolmens), dotted liberally along the Hondsrug, an elevated fringe along the province's eastern portion.