On the south side of Plaza Mayor, carved images of Pizarro and his lover Inés Yupanqui (sister of the Inca emperor Atahualpa) adorn the corner of the 16th-century Palacio de la Conquista. To the right is their daughter Francisca Pizarro Yupanqui with her husband (and uncle), Hernando Pizarro. The mansion was built in the 1560s for Hernando and Francisca after Hernando (the only Pizarro brother not to die a bloody death in Peru) emerged from jail after 20 years for murder.

Higher up, a bas-relief carving shows the Pizarro family shield (two bears and a pine tree), the walls of Cuzco (in present-day Peru) and Pizarro's ships.