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Shimmering titanium Museo Guggenheim Bilbao is one of modern architecture's most iconic buildings. It has almost single-handedly lifted Bilbao out of its post-industrial depression and into the 21st century – and with sensation. It boosted the city’s already inspired regeneration, stimulated further development and placed Bilbao firmly in the international art and tourism spotlight.

Some might say, probably quite rightly, that structure overwhelms function here and that the museum is more famous for its architecture than its content. But Canadian architect Frank Gehry’s inspired use of flowing canopies, cliffs, promontories, ship shapes, towers and flying fins is irresistible.

Gehry designed the museum with historical and geographical contexts in mind. The site was an industrial wasteland, part of Bilbao’s wretched and decaying warehouse district on the banks of the Ría del Nervión. The city’s historical industries of shipbuilding and fishing reflected Gehry’s own interests, not least his engagement with industrial materials in previous works. The gleaming titanium tiles that sheathe most of the building like giant herring scales are said to have been inspired by the architect’s childhood fascination with fish.

Other artists have added their touch as well. Lying between the glass buttresses of the central atrium and the Ría del Nervión is a simple pool of water that emits a mist installation by Fuyiko Nakaya. Near the riverbank is Louise Bourgeois' Maman, a skeletal spider-like canopy said to symbolise a protective embrace. In the open area west of the museum, the child-favourite fountain sculpture randomly fires off jets of water. Jeff Koons’ kitsch whimsy Puppy, a 12m-tall Highland Terrier made up of thousands of begonias, is on the city side of the museum. Bilbao has hung on to ‘El Poop’, who was supposed to be a passing attraction as part of a world tour. Bilbaínos will tell you that El Poop came first – and then they had to build a kennel behind it.

Heading inside, the interior is purposefully vast. The cathedral-like atrium is more than 45m high, with light pouring in through the glass cliffs. Permanent exhibits fill the ground floor and include such wonders as mazes of metal and phrases of light reaching for the skies.

For most people, though, it is the temporary exhibitions – from the life work of Yoko Ono to the extraordinary sculptures of Brazilian Ernesto Neto – that are the main attraction.

Admission prices vary depending on special exhibitions and time of year. The prices listed here are the maximum (and most common); the last ticket sales are half an hour before closing. Free guided tours in Spanish take place at 12.30pm and 5pm; sign up half an hour before at the information desk. Tours can be conducted in other languages but you must ask at the information desk beforehand. Groups are limited to 20 (and there needs to be a minimum of eight), so get there early. It’s also possible to organise private group tours with advance request in Spanish, English, French and German, among others. The museum is equipped with specially adapted magnetic loop PDA video guides for those with hearing impairments. Excellent self-guided audio tours in various languages are free with admission and there is also a special children's audio guide. Entry queues can be horrendous, with wet summer days and Easter almost guaranteeing you a wait of over an hour. The museum is wheelchair accessible.