Santiago's most important church is stunning both inside and out. There has been a cathedral on this site since the city's inception in the 1520s, though a series of pirate raids, earthquakes and dodgy architects put paid to at least three previous incarnations. The present cathedral, characterized by its two neoclassical towers, was completed in 1922; the remains of first colonial governor, Diego Velázquez, are still buried underneath.
The church was restored both inside and out for Santiago's quincentennial in 2015. Expect intricate ceiling frescoes, hand-carved choir stalls and a polished altar honoring the venerated Virgen de la Caridad.