This, the first winery in the Americas, was established at Parras in 1597, a year before the town itself sprang up. It’s now an industrial-sized operation exporting wine all over the world, although it's still housed on pleasingly old-fashioned premises. Casa Madero offers half-hour tours through the history of winemaking, discovering equipment old and new.
You can buy quality wine and brandy on-site too. From near the main plaza in Parras, catch one of the regular buses (M$20) that pass the winery; just tell your driver where you want to get off. Or take a taxi (M$100); the winery is 7km north of Parras.