This, the first winery in the Americas, was established at Parras in 1597, a year before the town itself sprang up. It’s now an industrial-sized operation exporting wine all over the world, although it's still housed on pleasingly old-fashioned premises. Casa Madero offers 45-minute tours through the history of winemaking, featuring equipment old and new.
You can buy quality wine and brandy on site though there are no tastings, unfortunately. From near the main plaza in Parras, catch one of the regular buses (M$20) that pass the winery; just tell your driver where you want to get off. Or take a taxi (M$80); the winery is 7km north of Parras.