For authentic end-of-the-earth ambience, this remote island wins the contest without even campaigning. Located south across the Beagle Channel from Ushuaia, it's a mostly uninhabited wilderness of peat bogs, southern beech forest and jagged, toothy spires known as Dientes del Navarino, also a famed trekking route. By a quirk, the island is considered by Santiago to be part of Chilean Antarctica, not Chilean Tierra del Fuego or Magallanes. Puerto Williams is the only town, the official port of entry for vessels en route to Cabo de Hornos and Antarctica, and home to the last living Yaghan speaker.
A permanent European presence was established on the island by mid-19th-century missionaries who were followed by fortune-seekers during the 1890s gold rush. Current inhabitants include the Chilean navy, municipal employees and octopus and crab fishers. The remaining mixed-race descendants of the Yaghan people live in the small coastal village of Villa Ukika.