For nymph fly-fishing along the Colorado River, call Lees Ferry Anglers for current conditions and to arrange a guided trip.
Guided fly-fishing trips (for one/two/three people $425/525/625) can accommodate up to three passengers per boat. Non-fishing guests pay $20 each. The rates are the same for guided spin fishing on the river. If you don't need a guide, you can just rent a boat for $300 per day.