The city is generally pretty friendly to travelers with disabilities, as most businesses are in compliance with ADA regulations. But the uneven sidewalks and alleyways aren't great for wheelchairs, and while all taxis can carry a folded wheelchair in the trunk, none offer lifts.
There's free parking for people with disabilities in government-run parking areas, including for garages and meters. Visitors with disabilities can find more info and contact information at www.charlestoncvb.com/travel-support/accessibility.
Accessible Travel Online Resources
Download Lonely Planet's free Accessible Travel guides from http://lptravel.to/AccessibleTravel.