For the vast majority of people on this forum flying is the only option to SEA.
also many of those visiting will want to visit the more touristy places and would be uncomfortable in the non tourist places
fine advice in principle but not so practical
If you're from Australia, Europe or North America, yes you fly to SE Asia but once you've landed at your gateway city, you can travel by land from there. Singapore is an important gateway city for flights from Australia, Europe and North America, while Bangkok serves the same purpose for flights arriving from Australia/NZ and Europe but not North America (since 2015 no airline operates a direct route between Bangkok and North America).
Why would anyone be "uncomfortable" traveling in the non-touristy places? If you don't want to visit non-touristy places, why even come?
I recently met a young American family. First time in Asia. They fly from Kuala Lumpur to Chiang Mai. After a couple of days there to get acclimatized, they catch a bus down to Lampang. Lampang receives the odd foreign traveler but for whatever reason still hasn't made it on the travel radar very much. That's where I meet them. At a very nice authentic Italian restaurant. They rent a car and check out a nearby dam where they go fishing, then they head up to Wat Chaloem Prakiat up on top of a limestone karst in the north of the province. A few days later, they catch a bus down to Tak and head into a national park there. After just over two weeks in Thailand, they fly to Malaysia where their first stop is Penang (yes, a touristy city, but you can escape the crowds quite easily).
Some countries are more suited to "off the beaten track" travel than others, but Thailand is definitely one country where you can have a fantastic time if you skip the done to death tourist haunts and check out some smaller, less well known provinces.
