Traveling through Asia is easy and cheap by bus or train. For example, we paid $65 for an on/off bus ticket to travel the whole length of Vietnam over a month - from Hanoi in the north to Saigon in the south. A 3-day boat trip thorugh the Mekong Delta from Saigon to Phnom Penh in Cambodia cost us $35 each and that included hotels, breakfast and a whole bunch of tours to rice noodle factories etc. For that price they also shepherded us through the Cambodian border processing.
We are both comfortable riding/driving motorcycles. Is that what you are talking about? We rented them for day trips - usually for about $5 each per day. If you are planning on doing this I suggest you learn to ride wherever you are now. There is quite a bit of learning involved and in the cities of SEA while EVERYONE rides motorcycles that also means the traffic is horrendous and really scary. And dangerous. I don't recollect anyone actually asking to see our driver's licenses but even so, please make sure you are VERY confident of your skills before setting out. We chose to rent motorcycles, not in busy urban areas but in the countryside and those experiences were truly magical. But you can also ride behind. In the town of Dalat, Vietnam there are a group of motorcycle guides (called Easy Riders) who will take you out into the mountains for anything from daytrips to multi-week trips. They have powerful bikes and I chose to ride behind a driver/guide while my husband rode his own. Thus we had the benefit of a guide taking us through the mountain villages. The guide/bike cost us $25/day while Steve's rental was $5. Worth every penny.
If it is bicycles you are talking about then you also really need to get your skills and bottom ready for the trip. Spending hours on a bike is not easy on the body - you are in the elements rain and shine, very exposed to whatever is around you. The trip will take a LOT more planning as you won't be able to depend on the gringo trail as much to identify what places you can sleep in and so on. I would also make sure you ship your own bikes around with you. On several occasions we rented bicycles locally and these were TOTAL disasters. Dysfunctional, bald tires, chains that constantly came off, brakes I would not depend on. Inevitably we ended up walking them for miles.
But truly, local public transportation is cheap and easy. Then rent motor/bicycles as you go for specific excursions.
As to selling your house? Well, the old adage is always sell high, buy low. With the real estate market in the slumps most places in the world you would be looking at selling low, probably VERY low if you are eager to get going. By the time you return, you could well find yourself in your 50s and now priced out of the market.
My personal financial philosophy right now (at age 59) is that I will permit myself to spend as much of my savings as necessary over the next 20 years to totally enjoy traveling and whatever else life holds but when the body gives out I will still have my house (with its 2 rental suites downstairs) to augment my smallish pension and I will be okay. When the time comes to downsize I will have a nice big, well maintained home to trade for a comfy old/old age.