Our original plan is shown in subject. We are thinking of skipping Lauterbrunnen and spending more time in Lucerne (3 nights) then on to Locarno. Also thinking of skipping Venice (2 nights) and going directly to Rome. From a travel and cost standpoint this may make sense. Is *Lauterbrunnen/Wengen a must see?
With potentially 2 more nights where should we consider going if we skip Lauterbrunnen? We thought perhaps extending our Florence, Italy stay as an option. Cost is an issue.
Thank You in advance.

It appears this is only part of a larger itinerary. From the sound of it it is a 'If this is Thursday, this must be Belgium' itinerary. That is, too many places in too little time. One of the two commonest mistakes travellers make. The second is packing too much. How's your packing list?
I have been to all of the places you name in your thread. Staying in Lauterbrunnen I could easily suggest enough to occupy you for a week or more. The same is true of all the places you name. Are any of them 'must sees', who knows what you would consider a must see?
Quantity is not quality beaconridge and it is a common mistake to confuse the two. Here is my minimum reccommended stay for each place you have mentioned. (assuming a normal amount of interest in the normally considered interesting things. I have no idea what you consider a must see.)
Zurich, 4 nights/3 days. Lucerne, 4 nights/3 days. Lauterbrunnen, 7 nights/6 days. Locorno (I would change to Ascona) 5 nights/4 days. Venice 7 nights/6 days. Rome, 7 nights/6 days. Florence, 7 nights/6 days.
How much time were you planning for them all in total?
You got a lot of useful answers during the whole month of May. It's now up to you to decide what you skip and what you add.

neckervd and travelinstyle46,
Thanks for your input.
I could not agree more with both your responses.
Our trip is for 14 days on a limited budget but is a "bucket list" experience. We are relatively new to European travel and at my age I am looking to get as much input from experienced travellers before I forget where we are headed and which "Thursday in Begium" we are to plan for. I believe we have enough info to consider what places and times to visit.
I appreciate your time and will make plans accordingly.
Thank You