" Is there anything specific I need to know about driving from Naples to Sicily?"
You will waste your time.
"What would be the good place to stay somewhere about an hour from Naples airport and close to the route to Sicily? I presume there should be something with beaches"
I would drive up to Castellabate (medieval Unesco heritage hill town, sandy beaches below), according to viamichelin about 2 hrs from Capodichino airport and 6 hrs from the Messina ferry.
