Mingalaba (Hi in Burmese)
You should generally have no problems physically and as you are a previous runner you can easily do some basic pre exercise and be ready to do it. The 3 passes are very very demanding physically and the average Everest base camp Trekker does not do them as they are at the more extreme range of normal trekking activities. However, many people have done the passes and are at higher levels of fitness and ability than most Trekkers. You can try the first pass and if you have difficulty change the trekking plans and do the normal EBC and other sections.
No matter how fit anyone is it is unsure whether someone with no experience of high altitude will acclimatise but if you read and follow the many online forums, advice and information plus read a trekking guidebook you have a better chance of success. You will not know how you respond to altitude of around above 2500m until you are there and your body tries it out. Most people can function at altitude if you go slowly and on these Nepal treks there are 100,000 plus Trekkers every year do it but not the extreme high passes.
As a general indication there is a previous forum post discussing average USA population high altitude health statics and about 60% of people feel moderate affects and about 25% experience more than moderate affects, with about 10% who simply cannot do it. These affects are influenced by how one manages themselves properly, so for some people they can easily do it but miss-manage themselves by going too high too fast and fail, while others who are less good at high altitude succeeed because they manage themselves better. The figures I have given are very general so nobody get upset about them and are welcome scientifically and statistically to suggest otherwise.
For equipment list refer to past post below and you have option of carrying yourself a medium size backpack or use porter to carry for you https://www.lonelyplanet.com/thorntree/forums/asia-indian-subcontinent/nepal/trekking-gear-list
If you have a porter hired at $20 per day you will need a small pack to carry daily items like water bottle, money and passport, etc. you can also hire many equipment items cheaply for around $1 a day each item in Kathmandu.
Once you have done more research and reading you can come back with specific questions.
