You have ample opportunities for a "little road trip" using Orlando and/or Las Vegas as a base without the long slog across I-10.
South Florida offers everything from the Kennedy Space Center to South Beach to Everglades National Park to The Keys and Key West plus a half hundred more depending on your tastes.
Las Vegas offers a dozen or more spectacular national and state parks within a day's drive.
I recommend Google, Rand-MacNally, and AAA as resources to plan a "little road trip."
US66 basically no longer exists - mostly interstate now (I eshew Interstates).
I just drove Vegas to Jacksonville FL. Never been down there and I wanted to visit a foreign country (I'm from WA). I generally followed US90. A lot of it is 4 lane and mostly posted 60-65 mph but I took many alternate state and local roads. I took 4 weeks with stops/side trips in Natl parks/forrests, wildlife refugees, etc. campgrounds. And especially the Cajun country/Bayous/LaFayette before 90 drops into New Orleans. Then the LA,AL,MS, coast. If you're just trying to get there and don't have a week or two, just go I10, but you won't see anything but industry, big cities, and a bare hint of the deep south.
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