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The Radisson Ciudad Empresarial Hotel is in a sort of satellite city for business only and is not really near anywhere.
Unless you have a conference or something in the area I would suggest you stay elsewhere.

Las Condes or Providencia for instance.
In this upper price range the Park Plaza is nice.

LOCATION

Santiago Park Plaza
Av Ricardo Lyon 207, Providencia, Santiago, 6650385 Chile

Telephone: 56 2 372 4000 - 56 2 372 4010
Fax: 56 2 233 6668 - 56 2 233 8521

Here at least you can go out and wander around and have the pick of twenty good restauarants within a few blocks.

At airport, right after exiting customs, you will enter a circle of kiosks--hire a "remis" to take you to the Tribeca, which is quite a nice place--well located, good breakfast and snack food. Your 10-year-old might enjoy a "lomito" filet mignon sandwich instead of the usual hamburger. My kids loved the Recoleta Cemetery--and don't miss the self-guided tour of the historic convent in the chapel (go through the "secret door" on the left as you walk towards the altar! I have not found an ATM that will let me withdraw more than 1050 pesos each day, which is about $350. And after withdrawing that, the other ATMs say I have a zero allowance. No one seems to be able to help with this. By the way, I am a legal resident and am here 11 months of the year. Love it!

I agree with #10 as far as the hotel, unless you have a specific reason, better to stay somewhere more centrally located like Providencia.

In Chile, I have been able to take out up to 250,000-300,000 pesos at once from an ATM.

How much are doubles at the Tribeca? It looks pretty good.

I visited Colonia, Uruguay for a day trip and it was really beautiful and fun! I recommend it! We took buquebus (http://www.buquebus.com). I recommend getting the express catamaran, it is a very nice 1 hour trip. We took the fast boat one way and the slow boat on the return and really preferred the fast boat! The slow boat (3 hour trip) is cheaper and lets you sit outside on the upper deck which is nice but it takes a long time and has a weird shopping mall ambience, with a gift shop, video arcade, several bars, a canteen serving plastic-wrapped sandwiches, and the upper deck is very clogged with smokers.
We rented a motor-scooter near the ferry and it was really fun riding around! I recommend climbing up the lighthouse.
Buy your ferry tickets in advance (you can purchase online) because they can sell out.
have fun!