I travel a lot alone in Mexico (and the world) and have met many other women. The younger, prettier ones run into more trouble than us over-50 types. When you backpack, you'll run into other people, men and women, who may be interested in accompanying you to certain places. You can take combis and buses easily. Taxis are more iffy for a single woman. Guard your possessions and be aware of your own emotional reactions to people. Always. If you feel uncomfortable, vulnerable, or that an area is not safe for any reason at all (Dont' think about it, don't talk yourself out of the feelings) just get out of there as quickly as you can. Dont' worry about hurting someone's feelings, slapping a man's hand away or anything else. They have more respect for a woman who stands up for herself. If you feel creeped out by anyone on a bus, move up to the front where the driver is, or sit next to an older person. Travel as often as possible with others, talk to people, learn some Spanish (a lot if you can) and practice with hotel clerks, vendors in the markets, get easy with the language. This will help more than anything else. Make sure you lock doors, keep stuff locked up in the hostels with a good lock, and simply stay aware. If you drink, stay sober, don't drink too much. Doing drugs means you'll be in contact with cartel types and that is the worst idea in Mexico, hands down. Learn some basic self defense and practice it till you feel comfortable screaming, hitting, punching, and aren't afraid. When you are not afraid, it shows on your body and people who might want to take advantage will pick someone else. All that said,you will have the time of your life. You will make mistakes and be scared sometimes, but you will also experience some of the warmest people in the world, great food and scenery, and be impressed by ruins dating far back in time. Best of luck to you and keep your folks in the loop daily or at least every other day, so they know where you are and what your plans are. This is great insurance. If you dont' check in, I suspect they'll come looking for you! BTW, if you have a Verizon phone, you can get Mexico Talk and Text, and be in cell phone contact all the time with people back home. That ought to make your parents feel better about the whole trip.