What do you think of this itinerary?

I think it is a crazy tiresome trip to go from Vinales ALL the way to Santiago de Cuba in one day!
You arrive in SdC at 6:30 in the morning and do you think you will have energy enough to see the whole city after this Viazul trip?

No good idea ...
Forget it and do just the western half of Cuba.

Succes
CJ

Ehin, your schedule is precise but not realistic, you have not factored in transit time ie to get to the Viazul, to get to a casa, between days 5 to 8 you will be spending more than 48 hrs moving around.

Forget Santiago de Cuba and Bayamo and spend a few more days in and around Havana.

Havana to Santiago by bus is only 12 hrs ?

Thanks for the feedback. If I skip Santa de cuba, is there any any destinations in the western part of Cuba that i can add? It may seem hectic, but considering this maybe my only trip to Cuba in a lifetime, I would like to see and experience as much as possible.

Please feel free to suggest other destinations. I don't drive and am travelling alone so I can onyl count on public transport though.

Thank you.

greslogo, according to the viazul web site, there is a fast bus that only stops once and will arrive Santa de cuba in 12 hours and 20 minutes.

Alternative:
Skip Vinales and fly from Havana to SdC, from there go back to Havana by Viazul bus through: Bayamo, Camaguey, Trinidad, Cienfuegos in total 12 days.
But still, I would "only" go to Havana, Vinales, Cienfuegos and Trinidad in those 12 days ... well, maybe I would add 2 days at the beach of Varadero to relax.

Thanks, ehin.

Day 1 Arriveda Havana airport at 1410pm, night in a casa in havana
Day 2 Havana city, night in havana casa
Day 3 9am viazul to Vinales arrive Vinales at 1250pm. Vinales city sightseeing
Day 4 Day trip/tour to the nature outskirt of Vinales, night in Vinales
Day 5 1400pm bus from vinales-havana arrive 1730pmto trinidad
Day 6 Trinidad
Cienfuegos, Santa Clara, Varadero
Day 11 0730 morning bus to havana arrive havana at 1300, night in havana
Day 12 Fly back in afternoon from havana

Don't make the mistake to go to Santiago by night bus, lost of time for nothing. Stay in the western part and allow yourself some time to see and breathe Cuba. It's not a racing turf.

I would suggest concentrating on the western part of Cuba only. It is better to go to fewer places and see them well instead of rushing around. Save eastern Cuba for a future trip.