The Lost and Found is fairly remote in the Chiriqui highlands between David and Boca del Toro. Almost in the middle of the two. We just drove past there going to and from Bocas del Toro from Boquete.
Numerous buses pass the L&F almost every 30 minutes and, if your lucky, you may also be able to catch an empty cab or someone willing to share a ride, but don't depend on many passing. From the L&F, I'm sure you can hike the highlands and the availablity of buses will allow you to go to and from the various surrounding villages.
From what we saw on the L&F, you may need a 4x4 to get to it if you plan on having a vehicle. The entrance was fairly steep with a lot of loose rocks.
From the L&F to the Azero Peninsula it's about 3 to 4 hours. It may take longer by bus and depending on which beach town you intend to go to, it could add another 2 to 3 hours.
I would stay away from Bocas del Toro. We went as a family with our teenage boys and were turned off immediately by the amount of garbage in the streets and water, the packs of dogs and vultures rooting through the garbage, and the fact that we saw most shoreline homes and businesses still using over water outhouses to discharge untreated human waste. We were witness to the process.
If you intend to visit this area, I suggest you head to the Palmar Tent Lodge on Red Frog Beach on Bastimentos. The owner, Chris, is a great host and in his mid twenties like all of his clientele. The tents are very sturdy and contain real beds, clean linens, fans and mosquito nets. He has excellent bathroom facilities and showers. The kids there were great, either cooking hot dogs or frying bananas or chopping up fresh pineapples. Everything was shared. We had a great time and we're two old farts. I believe a tent for two is $45 night.
You'll be able to see wildlife anywhere in Panama, so don't worry about that. I don't know much about the Darien, but I wouldn't go there without a guide that knows the area. Also, you may get turned away by the police at the random check points. I don't know how far off the beaten path you want to go with potential predators.
Our "friends of friends" said the only ways to get to San Blas was to either go by boat or drive. If you want to go by boat the owner of the B&B we stayed at in Las Cumbres, which is a 10km drive north of PC, does private tours. I don't know what the rate is, but if your interested the B&B is called Paradiso Pequino and his name is Richard.
