La Ceiba is the closest and known for it's nightlife; there are probably some upscale places there/near. I'm not much of a city person and La Ceiba was pretty rough around the edges - not sure it's what you're looking for. There are some great jungle lodges near with rafting, hiking, horses, kayaking, etc., if that's of interest.
Copán Ruinas is about 6 hours from La Ceiba by bus or you can fly half of that and bus or shuttle the last 3 hours. You can fly from Roatán to San Pedro Sula, too, then bus the last 3 hours. I've had great experiences with Hedman Alas buses. Copán Ruinas is a town, not a city, with cobble-stone streets and bright colored buildings in a small grid surrounding the central park. There are great places to eat and salsa but It's really a cute town with friendly people and the beautiful Maya ruins of Tikal are just a kilometer or 2 away - easily walkable or you can hire a moto taxi. There are also great hiking ops, an exotic bird park, and a cool butterfly place close.
Pictures of all of the above can be found in the 3 Honduras sets linked with travelogues below. Let me know if you have specific questions. Congratulations and have a great trip!