There is no direct bus...
So either go back to SJ for a direct bus to Nicaragua Border, or to Managua with Tica Bus or King Quality. Its 6 hours from SJ to Border...
Otherwise, Quepos to Puntarenas, 2 hours, then Puntarenas to Liberia, about 2 hours, Then every 30 minutes in daylight there are buses from Liberia to Border, about 2 hours...long day no matter what.
Once across border, taxi hire to SJDS or to San Jorge for ferry to Ometepe...
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