#9
Its easy and safe (of course you want to use common sense like everywhere in,the world) to self-drive the Garden Route. Also, with 5-7 days you have a pretty good amount of time, and the end of september / beginning of october is a very good time to travel. The weather should be fine, it wont be too,hot , and not too busy (and expensive) as well.
Where you visit on the Garden Route depends on you, there is no right or wrong. Personally, I would include Tsitikamma NP for natural beauty, dramatic coast lines and great hiking opportunities. I also like Oudtshorn a lot (which isnt really on th GR) to visit the Cango Caves, enjoy a meerkat exprience and drive and experience the beautiful Swartberg pass.