blackberry77, you and your friend desperately need a guide book - Bradt is considered the best and I believe that all your questions are covered there.
Sammo's Guesthouse in Cape Coast is a good choice together with Amkred just behind it. Tro-tros for Takoradi leave at the very near roundabout if I remember correctly.
Not in the guide - a cheap place to eat in Cape: walk from Sammo towards Oasis (good place to hang out and meet other travelers) and it's the last food shack on the right side before Oasis. They only serve rice and chicken with veggie sauce (makes it easy to choose haha) but that sauce is worth killing for! They were open in the afternoon and night 2 years ago.

