Bikes can be rented at many train stations, including Arnhem, Nijmegen and Zwolle. Otherwise, there is invariably a rental outlet in town.
The LF3 national bike route (230km) links Arnhem with Nijmegen and further south to Maastricht. Heading north, it passes through Deventer and Zwolle en route to Friesland.
See www.hollandcyclingroutes.com for information.
Buses cover routes in more rural parts of the region.
Central Netherlands has excellent rail links with Amsterdam and the rest of the country: main town Arnhem in Gelderland is just one hour by train to/from Amsterdam. In Overijssel, the small town of Zwolle is a major rail junction and the transfer point for trains further north.