Buses and dalla-dallas run all day from Arusha (Tsh7000, two hours) and Karatu (Tsh2500, one hour) to Mto wa Mbu. You can also come from Arusha on the minibuses that run to Karatu. All vehicles stop along the main road in the town centre.
Car hire for trips to Lake Manyara and Tarangire National Parks (including fuel and driver US$150 to US$200) and to Ngorongoro Crater (US$200 to US$250) is available in Mto wa Mbu through the Cultural Tourism Program office and Twiga and Njake Jambo campsites.
The track north to Lake Natron begins here.