In the past, a low-grade armed conflict in the Casamance meant travellers had to be particularly cautious in the area. Following a ceasefire in 2014, however, the situation has improved; as of early 2017, it felt quite safe travelling through this region. There is still a noticeable army presence here, however, and manned checkpoints along the main highways.
It's wise to seek the latest safety information from the Office de Tourisme in Ziguinchor or from Casamance-based hotels before visiting.
As a precaution, don't travel after dark and don't venture off into the bush without a trustworthy guide.