A quintessential Azuero town, La Villa de Los Santos is where Panama’s first move toward independence from Spain began on November 10, 1821. Residents now honor their freedom-fighting forebears by holding truly wild parties on that date. In fact, the local calendar does not skimp on celebrations, making it a very entertaining destination.
Aside from its festivals, Los Santos (as it's usually called) boasts colonial structures dating back to the early days of the Spanish settlement. It is also home to a modest but noteworthy museum dedicated to Panamanian independence as well as one of the country’s most magnificent churches.