As few streets are named and fewer houses are numbered, Nicaraguans use a unique system for addresses. They take a landmark, then give the distance from it in blocks, using cardinal points for directions.
For example, 'de la universidad, 2c S, 1c E' would be two blocks south, then one block east from the university. Some locals use arriba (up) and abajo (down) to refer to east and west respectively, terminology derived from the rising and setting of the sun.
We sometimes provide other landmark-based addresses such as 'frente catedral' (in front of the cathedral) in Spanish, so that locals can point you in the right direction.