Siuna–Bilwi (Puerto Cabezas)–Waspám & Río Coco
We won’t sugarcoat this: you’re in for a grueling ride on a beat-up old school bus packed to the gills. It begins with a 10- to 12-hour bus ride from Managua to Siuna in Las Minas, where you can access the Reserva de Biosfera Bosawás (Bosawás Biosphere Reserve). From Siuna, it’s another 10 to 12 hours on a horrendous road to Bilwi. Waspám and the Río Coco are a smoothish six hours north from there.
Juigalpa–El Rama–Bluefields–Corn Islands
The (much!) preferred trip to the crystalline Caribbean Sea unfurls on the smooth, paved road to El Rama, with rejuvenating side trips to the mountain towns of Boaco and Juigalpa. From El Rama, you can hop on a testing five-hour bus journey along the rutted dirt road to Pearl Lagoon, or take a convenient two-hour fast boat ride down the Río Escondido to Bluefields, from where there are twice-weekly boat services to the Corn Islands and daily speedboats to Pearl Lagoon.