Guadalajara’s old bus terminal is the Antigua Central Camionera, about 2km south of the cathedral near Parque Agua Azul. From here 2nd-class buses serve destinations within 100km of Guadalajara. There are two sides to it: Sala A is for destinations to the east and northeast; Sala B is for destinations northwest, southwest and south. There’s a M$0.50 charge to enter.
Bus services generally run between 6am and 10pm. Buses leave multiple times an hour for nearby locations, and once an hour or so for longer trips.