Catania Fontanarossa (www.aeroporto.catania.it), 62km north of Syracuse and easily reached on the A18 motorway, is the closest major airport. It's served by numerous airlines with connections to many Italian cities and destinations across Europe. Interbus runs frequent services between the airport and Syracuse (€6.20, 1¼ hours). It also runs direct services to Noto (€8.40, 1½ to 2¾ hours) and Ragusa (€8.60, 1¾ hours). Reduced service on Sunday; check times on the Interbus website.
A small number of flights to Italian and European cities also fly from the much smaller Comiso Airport, 27km northwest of Ragusa.
From Catania to the north, TTT Lines runs a nightly ferry service to Naples. Fares per person for a poltrona (airline-type armchair) start from €13.50. A double cabin starts from €126. Journey time is roughly 12 hours.
From May through September, Virtu Ferries runs daily ferries to Malta (1¾ hours) from Pozzallo, 64km southwest of Syracuse and 18km southeast of Modica. Fares vary depending on length of stay in Malta (same-day adult return €87 to €138, open return €115 to €163 depending on the season).
Both Interbus and AST connect southeastern Sicily to other parts of the island. SAIS Trasporti runs overnight services between Sicily's southeast and mainland Italy. From Noto, for example, destinations include Bari (€40, 10 to 11 hours), Naples (€43, 12 hours) and Rome (€43, 12¾ to 13 hours). See the SAIS Trasporti website for all routes, times and prices.
Car & Motorcycle
The A18/E45 motorway is the main gateway into southeastern Sicily, connecting Syracuse to Catania and its airport and, further north, to Taormina and Messina. From the latter, car ferries and hydrofoils cross the Strait of Messina to mainland Italy.
From Syracuse, up to 11 trains depart daily for Catania (from €6.90, one to 1½ hours) and Messina (from €10.50, 2½ to 3½ hours). Some go on to mainland Italy.