The town's central focus is Piazza del Popolo, which is a striking square dominated by the ornate bulk of the 18th-century Chiesa di San Sebastiano and Palazzo Municipale, Palazzolo's Liberty-inspired, early-20th-century town hall. From here you can take a short walk north that will bring you to Piazza Moro as well as two other exquisite baroque churches, the Chiesa Madre and Chiesa di San Paolo.

These two churches, the first on the square's southern flank and the second on the northern side, form a theatrical ensemble of columns, gargoyles and fleurs-de-lis. At the top of Via Annunziata (the main road leading right out of Piazza Moro) is the fourth of the town's baroque treasures, the Chiesa dell'Annunziata, with a richly adorned portal of twirling columns.