Sicily in general is a welcoming and safe place for women travellers, including those travelling solo. Cultural stereotypes of Italian men harassing lone foreign women are largely outdated and exaggerated.
That said, eye-to-eye contact remains the norm in Italy’s daily flirtatious interplay, and with some men this may segue into overt staring. Usually a simple show of disinterest is enough to nip unwanted attention in the bud. If ignoring them doesn’t work, politely say that you’re waiting for your marito (husband) or fidanzato (boyfriend) and, if necessary, walk away. If you are visibly in distress, people near you or passersby will generally step in to assist.