The northernmost sliver of the Galilee – bounded on the north and west by Lebanon, on the east by the Golan and on the south by the Hula Valley – is home to nature reserves, excellent museums, fine restaurants and villages with plenty of B&Bs. Many of the area's sites are along Rte 99, which runs more or less parallel to the Lebanese frontier on its way from Kiryat Shmona eastward to Mas'ada. The Golan's Banias Nature Reserve is 5km east of the Tel Dan Nature Reserve.

Known in Hebrew as Etzba HaGalil (literally 'the Galilee finger'), the Galilee Panhandle got its English name because the area's elongated shape reminded people of such American geographical features as the Texas Panhandle.