City buses vary from cheap, former US school buses (L10) to faster minibuses known as rapiditos (L15), both of which can be dirty and dangerous. Theft is common and gangs sometimes target buses. Stick to taxis.
Car & Motorcycle
Taxis cruise all over town; a ride costs L80 to L150 depending on the distance. It's always best to call a trusted taxi company rather than stopping one on the street. Teguber is Tegus's answer to Uber and works via an app that's worth downloading if you're going to spend any amount of time in the city. For a reliable traditional taxi company, try Radio Taxi Mall, which responds to phone and Facebook Messenger inquiries. If you find a driver you like, take their number so you can hire them throughout your stay.
There are a couple of useful downtown taxi colectivo stops: one on Calle Morelos that is particularly helpful for the airport, and another between Parque Valle and Parque La Merced that runs to the Mercado Jacaleapa terminal (where buses depart for El Paraíso and Danlí). They each charge L10.