The Romantic Road Coach stops in the main bus park at the Hauptbahnhof and on the more central Schrannenplatz.
The A7 autobahn runs right past town.
You can go anywhere by train from Rothenburg, as long as it’s Steinach. Change there for services to Würzburg (€15.70, one hour and 10 minutes). Travel to and from Munich (from €29, three to four hours) can involve up to three different trains, making a day trip from the capital unfeasible.