Frequent trains link Beaune and Dijon with other destinations in France. The region's two main TGV hubs are at Dijon and Montbard.
Two main autoroutes connect Côte d'Or with the rest of France. The A6 from Paris to Lyon passes through Semur-en-Auxois near Côte d'Or's northwestern corner and continues southeast to Beaune, where it joins up with the A31. The A31 runs north from Beaune through Dijon, continuing north all the way to France's border with Luxembourg.
Eurolines offers bus service from Dijon to other cities throughout Europe. Transco also runs buses to a few destinations in neighbouring départements, such as Avallon.