Though settled since prehistoric times and cultivated by the Celts in 1500 BC, it wasn't until the Romans arrived in 58 BC that Alsace really made the history books. Alsace formed part of Germania Superior in the Roman Empire, and the Romans made their mark building forts and camps such as Argentoratum (modern-day Strasbourg).

As the influence of the Roman Empire waned, the Alemanni (Germanic tribes from the Upper Rhine) seized power, bringing with them the dialect that forms the basis of present-day Alsatian, but they were soon ousted by Frankish Merovingians in the 5th century.

Under Charlemagne (742–814), the church gained influence and Alsace flourished. Over the following eight centuries, Alsace prospered as part of the Holy Roman Empire. Thanks to the imperial clout of the Hohenstaufen emperors, the 12th and 13th centuries were a golden age, with the rise of guilds and a prosperous merchant class, the expansion of towns and cities, and the construction of Romanesque churches. Alsace became a cradle of intellectual and artistic activity in the 15th century. The final stone was laid on its Gothic crowning glory, Strasbourg's Cathédrale Notre-Dame, in 1439.

French influence in Alsace began during the Wars of Religion (1562–98) and increased during the Thirty Years War (1618–48). Most of the region was attached to France in 1648 under the Treaty of Westphalia.

By the time of the French Revolution, Alsatians felt more connected to France than to Germany, but time did little to dampen Germany’s appetite for the region they called Elsass. When the Franco-Prussian War ended in 1871, an embittered France was forced to cede Alsace to the Kaiser. The region was returned to France following Germany’s defeat in WWI, but it was re-annexed by Nazi Germany in 1940.

After WWII Alsace was once again returned to France. Intra-Alsatian tensions ran high, however, as 140,000 Alsatians – as annexed citizens of the Third Reich – had been conscripted into Hitler’s armies. These conscripts were known as the ‘Malgré-Nous’ (literally ‘despite ourselves’) because the majority went to war against their will. To make Alsace a symbol of hope for future Franco-German (and pan-European) cooperation, Strasbourg was chosen as the seat of the Council of Europe (in 1949) and, later, of the European Parliament.