Sadly, Quito is not an easy city for disabled travelers to move around. There are few wheelchair ramps or accessible buildings, and the Old Town's narrow sidewalks are often potholed. The city's eastern and western neighborhoods are built on the lower slopes of the mountains, with pedestrian access often taking the form of extremely steep sidewalks or even steps.
However, the city's trolley bus system is wheelchair accessible and Ecuadorian's with disabilities do use public transport, usually with the help of others. Many hotels have accessible, ground-floor rooms, but the best bet may be one of the city's international chain hotels.