Most travelers tend to stay near Mariscal Sucre (known as the Mariscal), a guesthouse- and hostel-packed district. The quieter neighborhood of La Floresta is a pleasant alternative and begins only a few blocks away. There's a good range of accommodations in the Old Town (including most of Quito's best top-end hotels), which offer easy access to its museums, churches and other sights. Here, a lack of nightlife is the downside.
Practical Tip: Airport Accommodations
Following the opening of the city's first airport hotel, sleek Wyndham Quito Airport, there's talk of several other international chain hotels setting up properties at the airport. Alternatively, a cozy and lovely place located only 10km away is the family-run Posada Mirolindo. Worth considering for those with early flights to the Galápagos or the Amazon.