Buses leave from the plaza approximately every hour during daytime; the last bus is at 6pm. The main destination is Tena ($1, one hour), from where you need to change to destinations further afield.
You can also catch a Compañía Trans Dumbiki camioneta on the plaza for nearby destinations, as well as to Tena and beyond.
The need for passenger canoes has dried up thanks to the Tena–Coca (Loreto) road and others along the Río Napo. You can arrange trips with boat drivers on the beach for about $30 per hour, but nearby agencies offer better deals.