Generally, women travelers will find Ecuador safe and pleasant, despite the fact that machismo is alive and well. Ecuadorian men often make flirtatious comments and whistle at single women, both Ecuadorian and foreigners. The best strategy is to ignore them.
On the coast, come-ons are more predatory, and solo female travelers should take precautions such as staying away from bars and discos where they’ll obviously get hit on and opting for taxis over walking etc. Do not accept drinks from strangers – and don't leave your drink unattended. There are occasional reports of drugging.
Lonely Planet has received warnings in the past from women who were molested while on organized tours. If you’re traveling solo, it’s essential to do some research before committing to a tour: find out who’s leading the tour, what other tourists will be on the outing and so on. Women-only travel groups or guides are available in a few situations.