Prague and the Czech Republic are behind the curve when it comes to catering to travellers with disabilities. Cobblestones and high curbs present challenging mobility issues, and many older buildings, including hotels and museums, are not wheelchair accessible. The situation is better with newer buildings. Many big-name fast food restaurants are wheelchair-friendly.
In terms of public transport, Prague is slowly making progress on accessibility. Some buses and trams are low riders and, in theory, should accommodate a wheelchair. These services are marked on timetables with a wheelchair symbol. A handful of metro stations, including newer stations, are equipped with lifts. Consult the Prague Public Transport Authority (www.dpp.cz) website for details.