Healthwise, the Czech Republic poses no unusual threat or danger, and the worst you’ll probably get is a stomach upset or dehydration from too much beer the night before.
The European Health Insurance Card (EHIC) entitles EU citizens to the same emergency health-care benefits as local citizens receive from their national health care; therefore, most emergency care in the Czech Republic will be free for EU citizens, but transporting you to your home country, if you fall ill, will not be covered.
Citizens from other countries should find out if their personal insurance policy covers them abroad. Doctors expect cash if you do not have a national or European health-insurance card; make sure your insurance plan will reimburse your expenses.
Regardless of whether or not you carry an EHIC card, it's always wise to bring cash, a credit card and a valid passport to any hospital or emergency clinic.
There are no specific vaccinations required for entry to the Czech Republic.
The World Health Organization (WHO) recommends that travellers should be covered for diphtheria, tetanus, pertussis, measles, mumps, rubella and polio, as well as hepatitis B, regardless of their destination. Since most vaccines don’t produce immunity until at least two weeks after they've been given, visit a physician at least six weeks before departure.
Tap water in Prague and other large cities is safe to drink. Opt for bottled water in rural areas.
The level of health care in the Czech Republic is high, and all cities and large towns will have a hospital or clinic offering emergency medical treatment. Prague has several hospitals that are used to treating visiting foreigners. Costs are reasonable and generally lower than in Western Europe, and much lower than in the US.